What Is 7-Hydroxymitragynine?
- February 2026
- By: Avery Fritz
7-hydroxymitragynine is a naturally occurring kratom alkaloid found in Mitragyna speciosa, the tropical tree native to Southeast Asia commonly known as kratom. Among the plant’s more than 40 known alkaloids, 7-hydroxymitragynine—often shortened to 7-OH—is notable for its high potency, even though it occurs in only trace amounts in raw kratom leaves.
While mitragynine is the most abundant alkaloid in kratom, 7-hydroxymitragynine is considered one of the most potent. Its role in shaping the overall kratom potency profile is significant, especially when it comes to extract products or ultra enhanced kratom varieties.
How Is 7-Hydroxymitragynine Produced?
Despite its importance, 7-hydroxymitragynine is not a dominant component of the kratom leaf. In fact, it typically makes up less than 0.01% of the leaf’s total alkaloid content.
Two Main Ways 7-OH Appears:
1. Naturally in Kratom Leaves:
In its natural form, 7-hydroxymitragynine is present in very small amounts. It exists as part of the kratom plant’s native alkaloid structure, but not at levels that would dominate the user experience.
2. Through Metabolic Conversion:
After kratom is consumed, a portion of the mitragynine is converted in the body into 7-hydroxymitragynine via liver enzymes. This conversion process is one of the reasons why different methods of consuming kratom can lead to different perceived effects.
3. In Kratom Extracts and Enhanced Products:
Some ultra enhanced kratom or enhanced Bali kratom products are manufactured with elevated concentrations of kratom alkaloids—including isolated or lab-converted 7-hydroxymitragynine. These products tend to deliver stronger results but also require careful labeling to ensure users are informed.
Why 7-Hydroxymitragynine Matters
Understanding 7-hydroxymitragynine helps explain why different kratom products vary so widely in strength. While mitragynine is often used as the standard metric for potency, the presence of even a small amount of 7-OH can significantly affect a product’s overall alkaloid profile.
Some reasons this alkaloid is worth understanding:
- It’s highly active: Though present in small quantities, 7-OH is considered highly physiologically active compared to other alkaloids.
- It contributes to kratom potency: Especially in concentrated products or extracts, 7-hydroxymitragynine can elevate the overall intensity of the experience.
- It’s used in research: 7-OH is frequently studied to better understand kratom’s effects and chemical complexity (see PubChem).
Common Myths About 7-OH
There’s a lot of confusion surrounding 7-hydroxymitragynine. Let’s clear up some of the most common myths:
Myth 1: Kratom leaf contains a lot of 7-OH.
Reality: The raw plant contains very low levels—usually under 0.01%. Most of the 7-OH effect comes from the body metabolizing mitragynine after consumption.
Myth 2: More 7-OH always means better kratom.
Reality: Potency doesn’t always equal quality. Some users prefer lower alkaloid levels for consistency and smoother experiences, especially when incorporating kratom into a daily routine.
Myth 3: 7-OH is only found in extracts.
Reality: It exists in natural kratom but at extremely low levels. Extracts may feature elevated concentrations, but 7-OH is not exclusive to them.
Does 7-Hydroxymitragynine Exist in Other Plants or Foods?
Currently, 7-hydroxymitragynine is unique to the kratom plant and has not been identified in any other known food or botanical. Its structure and formation are specific to Mitragyna speciosa, and there are no natural dietary sources of this compound beyond kratom-derived products.
Why Accurate Labeling Matters
Due to its strength and activity, 7-hydroxymitragynine is a key focus in kratom testing and quality assurance. At Kratom Spot, our products undergo rigorous third-party lab testing to analyze alkaloid content, including mitragynine concentration. While 7-OH isn’t usually listed in natural kratom powders due to its trace levels, it may appear in some enhanced blends and extracts.
Shoppers seeking consistent experiences should always look for:
- Transparent lab testing
- Clearly labeled alkaloid concentrations
- Reliable sourcing for enhanced kratom products
Want to learn more about alkaloids and how they shape your kratom experience? Check out our Kratom Alkaloids Guide.
Final Thoughts
Though it may be present in only minute amounts, 7-hydroxymitragynine plays an outsized role in kratom’s complexity. It’s a naturally occurring part of the plant—but one whose strength and effects make it important to understand, especially when comparing traditional leaf powder to enhanced products.
At Kratom Spot, we believe informed customers make safer, smarter choices. That’s why we emphasize education, lab testing, and transparency across our product lines.